We investigate the molecular and cellular mechanisms that govern time control in animal development and developmental metabolism. In particular, we focus on the emerging concept of autonomous clocks — cellular timing mechanisms that are normally entrained by CDK-Cyclins and/or the circadian clock to run synchronously with master temporal programs, but can also operate autonomously to time and trigger a number of sub-cellular events with various roles in physiology. Conversely, we are also interested in uncovering the molecular circuits and metabolic sustenance programs that underlie the suspension of biological time, such as during cellular quiescence, senescence and dormancy.

As precise temporal control of development, metabolism and aging is essential for maintaining healthy physiology and preventing disease, our studies on the principles of biological timing are critical beyond their basic biology, promising impact in physiology or medicine.